Main pageKEGG pathway → Base excision repair

KEGG pathway: Base excision repair

Pathway hsa03410
Name Base excision repair
Members NEIL3 PCNA POLE2 PARP4 POLD2 POLE POLE3 POLD3 PARP1 APEX1 LIG1 PARP3 POLD1 POLD4 UNG HMGB1 APEX2 MUTYH FEN1 TDG LIG3 SMUG1 MPG MBD4 OGG1 NTHL1 XRCC1 NEIL2 POLE4 PARP2 POLB POLL NEIL1
Description Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.