Main pageKEGG pathway → PPAR signaling pathway

KEGG pathway: PPAR signaling pathway

Pathway hsa03320
Name PPAR signaling pathway
Members LPL PLTP DBI CD36 CPT2 ACOX2 FABP7 SCP2 ILK UBC ANGPTL4 OLR1 MMP1 FABP4 CYP27A1 NR1H3 FADS2 CPT1A ACOX1 ACSL1 PCK2 AQP7 ACAA1 ACADM EHHADH PPARA GK2 FABP5 UCP1 ACOX3 APOA1 APOC3 SLC27A6 FABP2 ADIPOQ CYP4A22 APOA2 HMGCS2 PCK1 APOA5 SCD5 ACSBG2 CYP7A1 CYP4A11 RXRA PLIN1 FABP1 ACSL5 SLC27A1 SLC27A5 CYP8B1 PPARD SORBS1 ACSL3 RXRB ACADL PPARG CPT1C SCD SLC27A4 PDPK1 ACSBG1 ACSL4 FABP6 RXRG ACSL6 ME1 SLC27A2 FABP3 CPT1B
Description Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.