Main pageKEGG pathway → Proteasome

KEGG pathway: Proteasome

Pathway hsa03050
Name Proteasome
Members PSMB9 PSME2 PSME1 SHFM1 PSMB10 PSMA2 PSME4 PSMC2 PSMA3 PSMA7 PSMB3 PSMF1 PSMA5 PSMB4 PSMD13 PSMB1 PSMC4 PSMD14 PSMD11 PSMB2 POMP PSMA6 PSMA4 PSMB6 PSMA1 PSME3 PSMB5 IFNG PSMD2 PSMD12 PSMB11 PSMA8 PSMC5 PSMB7 PSMD3 PSMD6 PSMD4 PSMD7 PSMC1 PSMD8 PSMC3 PSMC6 PSMD1
Description The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.