Main pageKEGG pathway → Spliceosome

KEGG pathway: Spliceosome

Pathway hsa03040
Name Spliceosome
Members SNRPG LSM2 SRSF3 HSPA6 NAA38 SNRPB THOC4 LSM5 U2AF1 TRA2A DDX23 LSM7 PHF5A SNRPE MAGOHB SNRNP40 RBMX THOC1 EIF4A3 SRSF10 SNRPF SNRNP200 BUD31 PRPF40A NCBP2 PRPF38A SRSF1 SRSF9 AC008073.5 SRSF6 EFTUD2 PRPF3 DHX15 THOC2 LSM6 RBM8A USP39 SF3B4 PRPF4 DDX5 MAGOH HNRNPM SNRPC HNRNPA1L2 PPIL1 TRA2B SNRPA SF3A3 DHX38 NCBP1 HSPA1A RBM22 U2AF2 PRPF38B SF3A2 SF3B3 SRSF7 PRPF31 SNRPD2 HNRNPK SF3B1 SNRPD1 SNW1 HNRNPA1 SYF2 DDX46 PPIH HNRNPA3 PRPF6 PPIE HNRNPU CTNNBL1 PUF60 HSPA1A HNRNPC SART1 SRSF2 ISY1 AQR DHX16 SNRPB2 PLRG1 CRNKL1 DHX8 SF3B5 SRSF4 U2SURP CDC5L ACIN1 CCDC12 LSM4 SNRNP70 THOC3 RBM17 PQBP1 SNRPA1 SMNDC1 RBM25 SF3B2 LSM3 KB-1995A5.13 PRPF8 CHERP PCBP1 BCAS2 XAB2 SRSF5 DDX42 WBP11 SF3A1 TCERG1 TXNL4A SNRNP27 HSPA8 ZMAT2 PRPF18 HSPA1L SLU7 CDC40 KB-1995A5.13 PRPF40B PRPF19 HSPA2 NHP2L1
Description After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.