Main pageKEGG pathway → RNA degradation

KEGG pathway: RNA degradation

Pathway hsa03018
Name RNA degradation
Members PABPC1L LSM2 BTG1 XRN2 NAA38 LSM5 PABPC1 LSM7 DCPS EXOSC8 BTG3 PAN2 PATL1 LSM6 BTG2 PNPT1 CNOT2 EXOSC10 LSM1 RQCD1 CNOT6 EXOSC4 EXOSC3 HSPD1 WDR61 CNOT10 PABPC4 HSPA9 TOB1 TOB2 DIS3 DHX36 ZCCHC7 CNOT1 PABPC3 CNOT8 TTC37 EDC3 PARN EXOSC9 XRN1 EXOSC7 ENO1 LSM4 SKIV2L SKIV2L2 EXOSC2 CNOT6L DCP1B PAN3 CNOT4 ENO3 LSM3 EXOSC6 DCP2 CNOT7 CNOT3 DDX6 BTG4 EXOSC5 MPHOSPH6 PAPD7 EDC4 EXOSC1 C1D PABPC5 ENO2 PABPC1L2A
Description The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.