Main pageKEGG pathway → mRNA surveillance pathway

KEGG pathway: mRNA surveillance pathway

Pathway hsa03015
Name mRNA surveillance pathway
Members PABPC1L NXT2 THOC4 PABPC1 NXT1 MAGOHB EIF4A3 MSI1 MSI2 NCBP2 NXF2 NXF2 CPSF3 CLP1 RBM8A CSTF2 MAGOH PAPOLA CPSF4 PPP2R1B PNN NCBP1 CPSF2 PABPC4 NXF1 ETF1 UPF3A CPSF1 UPF3B CSTF1 PABPC3 GSPT1 ACIN1 PPP2R3C PPP2R3B CSTF3 WIBG PCF11 SRRM1 UPF1 PAPOLG CASC3 SMG1 PABPN1L NUDT21 FIP1L1 DAZAP1 NXF3 GSPT2 PAPOLB PABPN1 SMG5 PPP2R5A PELO SMG6 CPSF7 NXF5 PPP2CB SAP18 PPP2R5C CPSF6 SYMPK SMG7 RNGTT PPP2R2A RNPS1 CSTF2T PPP2R3A HBS1L PPP2R5E PPP2CA RNMT UPF2 PPP2R5D PPP2R1A AC011357.1 PABPC5 PPP2R5B PPP2R2D PABPC1L2A PPP2R2C
Description The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.