Main pageKEGG pathway → RNA transport

KEGG pathway: RNA transport

Pathway hsa03013
Name RNA transport
Members EIF4EBP1 RPP21 PABPC1L TACC3 NUP37 NUP160 NUP205 NUP107 NXT2 NUP43 NUP188 SUMO4 THOC4 PABPC1 NXT1 NMD3 NUP35 EIF4A1 POP5 MAGOHB THOC1 EIF4A3 SEC13 NCBP2 NXF2 NUP155 EIF3G GEMIN6 NXF2 NUP54 EIF3B THOC6 GEMIN4 EIF3D THOC2 NUPL2 NUP88 NUP85 RBM8A TPR TMEM48 EIF3I AAAS MAGOH GEMIN5 PRMT5 UBE2I EIF4E2 PNN NUP62 NCBP1 EIF1AX XPO1 XPOT XPO5 GEMIN7 POP4 GEMIN8 NUP98 ELAC1 EIF2B2 CLNS1A EIF2B1 EIF5B EEF1A1 EIF3E PABPC4 NUP210 NXF1 RPP40 NUP153 DDX20 EIF4G2 EIF3F EIF3H PAIP1 EIF2S1 NUP133 EIF2S2 EIF2S3 TGS1 POM121C UPF3A KPNB1 PHAX UPF3B EIF2B4 PABPC3 RAE1 ACIN1 NUP214 NUP50 POM121 WIBG ELAC2 EIF4B POP1 SMN1 NUP93 EIF4G1 SUMO2 SRRM1 UPF1 THOC3 CASC3 EIF3J EIF1AY RAN EIF1 C9orf23 EIF2B5 NXF3 SIP1 SENP2 POP7 TRNT1 EIF2B3 SNUPN NUP210L RPP38 NUPL1 EIF5 SUMO1 NXF5 SAP18 EIF3A THOC5 RANBP2 RPP30 STRAP EIF1B EIF4E1B RNPS1 SEH1L EIF4G3 THOC7 UPF2 EIF4E EIF4A2 SUMO3 RPP25 PABPC5 RANGAP1 EEF1A2 PABPC1L2A RPP14
Description RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.