Main pageKEGG pathway → Ribosome biogenesis in eukaryotes

KEGG pathway: Ribosome biogenesis in eukaryotes

Pathway hsa03008
Name Ribosome biogenesis in eukaryotes
Members NXT2 XRN2 HEATR1 NXT1 GAR1 NMD3 WDR3 POP5 GNL2 DKC1 NVL NXF2 LSG1 UTP15 RBM28 FCF1 NOP10 NXF2 FBL SPATA5 UTP6 REXO2 WDR75 EIF6 RIOK1 GNL3L UTP14A XPO1 EFTUD1 POP4 RIOK2 NOP58 CSNK2B WDR36 WDR43 NXF1 NOB1 NHP2 RPP40 SBDS MPHOSPH10 UTP18 GNL3 NAT10 XRN1 RCL1 POP1 PWP2 TBL3 NOP56 TCOF1 IMP3 RAN C9orf23 CSNK2A2 UTP14C NXF3 REXO1L1 CIRH1A POP7 CSNK2A1 IMP4 RRP7A RPP38 NXF5 GTPBP4 BMS1 DROSHA RPP30 NOL6 MDN1 TAF9 TAF9 NHP2L1 RPP25 REXO1
Description Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.