Main pageKEGG pathway → Glycosaminoglycan biosynthesis

KEGG pathway: Glycosaminoglycan biosynthesis

Pathway hsa00534
Name Glycosaminoglycan biosynthesis
Members HS3ST3B1 EXT2 EXTL2 EXT1 B4GALT7 HS3ST1 B3GALT6 HS3ST3A1 XYLT2 EXTL3 B3GAT3 NDST1 HS6ST1 HS6ST2 NDST2 B3GAT2 HS2ST1 GLCE HS3ST5 XYLT1 NDST4 B3GAT1 EXTL1 HS3ST2 HS6ST3 NDST3
Description Heparan sulfate (HS) is a glycosaminoglycan with the basic disaccharide unit GlcNAc(a1-4)GlcA(b1-4), containing N- and O-sulfate esters at various positions. HS is covalently attached to serine residues in a proteoglycan core protein via the linkage tetrasaccharide. The addition of the first GlcNAc residue is catalyzed by EXTL3 glycosyltransferase, followed by the polymerization steps catalyzed by EXT1 and EXT2 transferases. As the chains polymerize, HS undergoes a series of modification reactions catalyzed by at least four families of sulfotransferases and one epimerase.