Main pageKEGG pathway → Other types of O-glycan biosynthesis

KEGG pathway: Other types of O-glycan biosynthesis

Pathway hsa00514
Name Other types of O-glycan biosynthesis
Members PLOD3 LFNG MFNG POFUT1 GLT25D1 POGLUT1 POFUT2 UGT2B17 UGT1A5 POMT2 UGT2B28 B4GALT1 GLT25D2 UGT2B7 UGT1A8 POMT1 POMGNT1 UGT2B10 UGT2B4 UGT2B15 B3GALTL GXYLT1 B4GALT3 UGT1A1 RFNG UGT2A3 UGT1A4 UGT2A1 FUT4 FUT7 UGT1A3 CHST10 UGT2B11 ST6GAL1 OGT UGT1A7 UGT1A10 UGT1A9 GXYLT2 B4GALT2 UGT1A6 ST3GAL3 ST6GAL2 MGAT5B FUT9
Description O-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or threonine residue, which is catalyzed by protein O-mannosyltransferases POMT1 and POMT2. Defects of these genes are linked to human diseases, such as muscular dystrophies caused by reduced O-mannosylation of alpha-dystroglycan in skeletal muscles [DS:H00120].