Main pageKEGG pathway → Mucin type O-Glycan biosynthesis

KEGG pathway: Mucin type O-Glycan biosynthesis

Pathway hsa00512
Name Mucin type O-Glycan biosynthesis
Members GALNT5 GALNTL2 GALNT10 GALNT1 GALNT2 GALNT3 C1GALT1C1 GALNT7 GALNT8 B4GALT5 GALNT12 C1GALT1 B3GNT6 GCNT3 ST3GAL2 ST3GAL1 ST6GALNAC1 GALNT6 GCNT1 GALNT11 GALNT13 GALNTL4 GALNTL1 GALNTL5 GALNT14 GCNT4 GALNTL6 GALNT9 WBSCR17
Description O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.