Main pageKEGG pathway → Cysteine and methionine metabolism

KEGG pathway: Cysteine and methionine metabolism

Pathway hsa00270
Name Cysteine and methionine metabolism
Members DNMT1 MPST MAT2A IL4I1 AHCY SMS ADI1 MTAP TST SRM LDHA MTR CTH DNMT3B CBS CDO1 DNMT3A LDHC MRI1 AHCYL1 APIP ENOPH1 LDHAL6B AHCYL2 TAT DNMT3L MAT1A IL4I1 MAT2B LDHB AMD1 LDHAL6A TRDMT1 SDS BHMT GOT2 GOT1
Description Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].