Main pageKEGG pathway → Primary bile acid biosynthesis

KEGG pathway: Primary bile acid biosynthesis

Pathway hsa00120
Name Primary bile acid biosynthesis
Members ACOX2 SCP2 HSD3B7 CYP27A1 HSD17B4 CYP39A1 AKR1C4 AKR1D1 CYP7A1 AMACR SLC27A5 CYP8B1 BAAT CH25H CYP7B1 CYP46A1
Description Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine.