Main pageKEGG pathway → Pentose phosphate pathway

KEGG pathway: Pentose phosphate pathway

Pathway hsa00030
Name Pentose phosphate pathway
Members PGM2 DERA H6PD FBP1 PGD PGLS RPIA TKTL1 RPE PGM1 TALDO1 PFKL TKTL2 PRPS2 TKT FBP2 RBKS G6PD PRPS1 RGN ALDOB ALDOA PFKM GPI PFKP ALDOC
Description The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].