Main pageKEGG pathway → Glycolysis / Gluconeogenesis

KEGG pathway: Glycolysis / Gluconeogenesis

Pathway hsa00010
Name Glycolysis / Gluconeogenesis
Members HK2 PGM2 PGAM2 GALM FBP1 PGK1 AKR1A1 ALDH3A2 ADH5 ADPGK BPGM ALDH1B1 ALDH7A1 HK3 GAPDH HKDC1 ALDH9A1 ADH4 LDHA PCK2 PGM1 ENO1 LDHC PFKL PDHA2 DLD LDHAL6B ADH7 ADH1A PGK2 ENO3 G6PC2 ADH6 ALDH3B2 FBP2 PCK1 ALDH3A1 GAPDHS GCK PKLR ACSS2 G6PC DLAT PDHB LDHB LDHAL6A ALDOB TPI1 PGAM4 ALDOA PKM2 PDHA1 ACSS1 PFKM PDHX ADH1B ADH1B ALDH1A3 GPI PGAM1 ALDH2 HK1 PFKP ALDOC ENO2
Description Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].